If you think your dog is showing signs of liver disease or if they've already been diagnosed by their veterinarian, rest assured that liver disease in dogs is common and, often times, highly treatable. Early detection can go a long way toward ensuring a happy, healthy outcome for your pet and preventing liver failure in dogs. The key is to look out for early warning signs, although many dogs with liver disease may not present any noticeable clinical signs, and to follow your vet's recommendations. Read on to learn how you can be a liver-conscious pet parent.
The Power of the Liver
The liver is an amazing, multitasking organ. Nestled between the stomach and the diaphragm, its job is as central as its location in the body. Its functions include:
- Digestive: It helps breakdown nutrients as well as digesting fat
- Antitoxic: The liver also detoxifies the blood
- Immunological: It can also make proteins that help with blood clotting
- Metabolic: The liver can help break down fats for energy and helps breakdown carbohydrates to regulate blood sugar
Causes of Liver Disease in Dogs
A dog develops liver disease when any of their liver's functions are disrupted. Here are a few of the most common conditions that lead to liver disease in dogs:
- Infectious hepatitis: Hepatitis is a general term that describes inflammation of the liver. Thankfully, vaccines can help prevent many of the infections that cause hepatitis.
- Toxic hepatopathy or Hepatotoxicity: There are a number of liver toxins that can cause liver disease in dogs, according to the Merck Veterinary Manual.
- Vacuolar (Endocrine) hepatopathy (VH): Cushing's disease, thyroid disease and diabetes are the most common endocrine diseases that can affect your dog's liver.
- Portosystemic shunts: When blood vessels bypass the liver, it can lead to an excess of toxins in the bloodstream and can cause liver disease.
- Liver cancers: Liver cancer can originate in the liver tissue or can spread there from other parts of the body.
- Inherited liver diseases: These include copper storage disease in Bedlington terriers and West Highland white terriers, among other breeds, and amyloidosis in shar-peis.
- Idiopathic chronic hepatitis: This inflammatory condition may be autoimmune in origin. It may also be influenced by infectious diseases of the liver.

While it seems like there's an overwhelming number of possible causes for liver disease in dogs, most are preventable and all are treatable to some extent.
Causes of Liver Failure in Dogs
Several main culprits of liver failure in dogs include:
- Ingestion of toxins, such as the artificial sweetener xylitol
- Excessive heat or heatstroke
- Infections
In all of these cases, early intervention can prevent your dog from having liver failure.